ea0031oc4.2 | Obesity, metabolism and bone | SFEBES2013
Morgan Stuart
, Bujalska Iwona
, Gathercole Laura
, Hassan-Smith Zaki
, Guest Phil
, Abrahams Lianne
, Stewart Paul
, Lavery Gareth
, Tomlinson Jeremy
Glucocorticoids (GC), such as prednisolone, are widely prescribed for their anti-inflammatory and immunosuppressive properties. However, they have significant side-effects including insulin resistance and hepatic steatosis. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts 11-dehydrocorticosterone (11DHC) to active corticosterone (CORT) and thus amplifies local GC action. We hypothesise that enhanced local GC regeneration of exogenously administered GCs by ...